Modulation of magnesium deficiency-induced anxiety and HPA axis dysregulation by therapeutic drug treatment
نویسندگان
چکیده
Background Preclinical and some clinical studies suggest a relationship between perturbation in magnesium homeostasis and pathological anxiety, although the underlying mechanisms remain largely unknown. Since there is evidence that Mg modulates the hypothalamic-pituitary-adrenal (HPA) axis, we tested whether enhanced anxiety-like behaviour can be reliably elicited by dietary Mg restriction and whether Mg deficiency is associated with altered HPA axis function.
منابع مشابه
Magnesium deficiency induces anxiety and HPA axis dysregulation: Modulation by therapeutic drug treatment
Preclinical and some clinical studies suggest a relationship between perturbation in magnesium (Mg(2+)) homeostasis and pathological anxiety, although the underlying mechanisms remain largely unknown. Since there is evidence that Mg(2+) modulates the hypothalamic-pituitary adrenal (HPA) axis, we tested whether enhanced anxiety-like behaviour can be reliably elicited by dietary Mg(2+) deficiency...
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